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Researchers confirm a primary cause of Alzheimer’s disease

Knowridge Science Report 1d

"\u003Chtml\u003E\n \u003Chead\u003E\u003C\u002Fhead\u003E\n \u003Cbody\u003E\n \u003Cdiv\u003E\n \u003Cdiv\u003E\n \u003Cdiv\u003E\n \u003Cdiv\u003E \n \u003Cdiv\u003E \n \u003Cfigure\u003E\n \u003Cspan class=\"view-HD-pictures-wrap\"\u003E\n \u003Cimg class=\"view-HD-pictures\" data-src=\"https:\u002F\u002Fres.6chcdn.feednews.com\u002Fassets\u002Fv2\u002F8cf07e0dac576d45185ad90595784117?source=nlp&quality=uhq&format=jpeg&resize=720\" alt=\"\" title=\"Researchers confirm a primary cause of Alzheimer's disease\" data-image-width=\"696\" data-image-height=\"464\"\u003E\n \u003Cspan class=\"view-HD-pictures\"\u003EView pictures in App save up to 80% data.\u003C\u002Fspan\u003E\n \u003C\u002Fspan\u003E\n \u003C\u002Ffigure\u003E \n \u003C\u002Fdiv\u003E \n \u003Cp\u003EIn a study from Yale-NUS College, researchers found evidence that metabolic dysfunction is a primary cause of Alzheimer’s disease.\u003C\u002Fp\u003E \n \u003Cp\u003EAlzheimer’s disease is the most common neurodegenerative disease affecting the elderly worldwide, as well as one of the most common causes of dementia.\u003C\u002Fp\u003E \n \u003Cp\u003EIn Singapore, one in 10 people aged 60 or above is believed to suffer from dementia.\u003C\u002Fp\u003E \n \u003Cp\u003EAfter more than twenty years of research effort worldwide, scientists are still unable to identify the exact causes of Alzheimer’s and no proven treatment is available.\u003C\u002Fp\u003E \n \u003Cp\u003ETwo competing theories are currently proposed to explain the cause of Alzheimer’s: the first is focused on the accumulation of a specific protein, called amyloid-beta protein, in the brain as the primary cause;\u003C\u002Fp\u003E \n \u003Cp\u003Ewhilst a second and more recent theory proposes that metabolic dysfunction, specific dysfunction of the cell’s energy-producing machinery called mitochondria is responsible.\u003C\u002Fp\u003E \n \u003Cp\u003EIn the study, the team discovered that metabolic defects occur well before any significant increase in the amount of amyloid-beta protein could be detected.\u003C\u002Fp\u003E \n \u003Cp\u003EThe team used a tiny worm called Caenorhabditis elegans to identify these changes because it shares many similarities at the molecular level with human cells.\u003C\u002Fp\u003E \n \u003Cp\u003EA further breakthrough came when the team found that treatment of the worms with a common anti-diabetes drug called Metformin reversed these metabolic defects and normalized the worms’ healthspan and lifespan.\u003C\u002Fp\u003E \n \u003Cp\u003EThe team says that based on the emerging strong links between mitochondrial dysfunction and Alzheimer’s pathology, it might be better to adopt a preventative strategy by targeting metabolic defects, especially mitochondrial defects, directly and early, well before protein aggregates are even present.\u003C\u002Fp\u003E \n \u003Cp\u003EHe further explained that metabolic and mitochondrial dysfunctions should be viewed as fundamental features of aging in general and that age-dependent diseases, including Alzheimer’s, should, therefore, be viewed as manifestations of aging.\u003C\u002Fp\u003E \n \u003Cp\u003EHence, it may be easier to prevent or treat age-dependent diseases by targeting the mechanisms of aging rather than treating individual diseases after symptoms occur.\u003C\u002Fp\u003E \n \u003Cp\u003EThe study was conducted by Jan Gruber et al, and published in the scientific journal \u003Ca href=\"http:\u002F\u002Fdx.doi.org\u002F10.7554\u002FeLife.50069\"\u003EeLife\u003C\u002Fa\u003E.\u003C\u002Fp\u003E \n \u003Cp\u003EIf you care about brain health, please read studies about \u003Ca href=\"https:\u002F\u002Fscientificdiet.org\u002F2022\u002F09\u002Fhow-mediterranean-diet-could-protect-your-brain-health\u002F\"\u003Ehow the Mediterranean diet could protect your brain health,\u003C\u002Fa\u003E and \u003Ca href=\"https:\u002F\u002Fscientificdiet.org\u002F2022\u002F08\u002Fstrawberries-could-help-prevent-alzheimers-disease-shows-study\u002F\"\u003EStrawberries could help prevent Alzheimer’s disease\u003C\u002Fa\u003E.\u003C\u002Fp\u003E \n \u003Cp\u003EFor more information about brain health, please see recent studies about \u003Ca href=\"https:\u002F\u002Fscientificdiet.org\u002F2022\u002F10\u002Fvitamin-d-deficiency-linked-to-higher-dementia-risk-study-finds\u002F\"\u003EVitamin D deficiency linked to higher dementia risk,\u003C\u002Fa\u003E and \u003Ca href=\"https:\u002F\u002Fscientificdiet.org\u002F2022\u002F08\u002Fthese-antioxidants-may-reduce-risk-of-dementia\u002F\"\u003Ethese antioxidants could help reduce dementia risk\u003C\u002Fa\u003E.\u003C\u002Fp\u003E \n \u003C\u002Fdiv\u003E\n \u003C\u002Fdiv\u003E\n \u003C\u002Fdiv\u003E\n \u003C\u002Fdiv\u003E\n \u003C\u002Fbody\u003E\n\u003C\u002Fhtml\u003E"

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